Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer
Identifieur interne : 001057 ( Main/Exploration ); précédent : 001056; suivant : 001058Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer
Auteurs : Alexandra C. Walls ; M. Alejandra Tortorici ; Berend-Jan Bosch [Pays-Bas] ; Brandon Frenz ; Peter J. M. Rottier [Pays-Bas] ; Frank Dimaio ; Félix A. Rey ; David VeeslerSource :
- Nature [ 0028-0836 ] ; 2016.
Abstract
The high-resolution cryo-electron microscopy structure of a pre-fusion coronavirus spike trimer from mouse hepatitis virus is presented; the structure reveals architectural similarities to paramyxovirus F proteins, suggesting that these fusion proteins may have evolved from a distant common ancestor.
The online version of this article (doi:10.1038/nature16988) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nature16988
PubMed: 26855426
PubMed Central: 5018210
Affiliations:
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id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.34477.33</institution-id><institution-id institution-id-type="ISNI">0000000122986657</institution-id><institution>Department of Biochemistry,</institution><institution>University of Washington,</institution></institution-wrap>Seattle, 98195 Washington USA</nlm:aff><wicri:noCountry code="subfield">98195 Washington USA</wicri:noCountry></affiliation></author></analytic><series><title level="j">Nature</title><idno type="ISSN">0028-0836</idno><idno type="eISSN">1476-4687</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">The high-resolution cryo-electron microscopy structure of a pre-fusion coronavirus spike trimer from mouse hepatitis virus is presented; the structure reveals architectural similarities to paramyxovirus F proteins, suggesting that these fusion proteins may have evolved from a distant common ancestor.</p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nature16988) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mclellan, Js" uniqKey="Mclellan J">JS McLellan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, Hs" uniqKey="Yin H">HS Yin</name></author><author><name sortKey="Wen, X" uniqKey="Wen X">X Wen</name></author><author><name sortKey="Paterson, Rg" uniqKey="Paterson R">RG Paterson</name></author><author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name></author><author><name sortKey="Jardetzky, Ts" uniqKey="Jardetzky T">TS 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S">S Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goddard, Td" uniqKey="Goddard T">TD Goddard</name></author><author><name sortKey="Huang, Cc" uniqKey="Huang C">CC Huang</name></author><author><name sortKey="Ferrin, Te" uniqKey="Ferrin T">TE Ferrin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emsley, P" uniqKey="Emsley P">P Emsley</name></author><author><name sortKey="Lohkamp, B" uniqKey="Lohkamp B">B Lohkamp</name></author><author><name sortKey="Scott, Wg" uniqKey="Scott W">WG Scott</name></author><author><name sortKey="Cowtan, K" uniqKey="Cowtan K">K Cowtan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, Y" uniqKey="Song Y">Y Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dimaio, F" uniqKey="Dimaio F">F DiMaio</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Chiu, W" uniqKey="Chiu W">W Chiu</name></author><author><name sortKey="Baker, D" uniqKey="Baker D">D Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Vb" uniqKey="Chen V">VB Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krissinel, E" uniqKey="Krissinel E">E Krissinel</name></author><author><name sortKey="Henrick, K" uniqKey="Henrick K">K Henrick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holm, L" uniqKey="Holm L">L Holm</name></author><author><name sortKey="Rosenstrom, P" uniqKey="Rosenstrom P">P Rosenstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corpet, F" uniqKey="Corpet F">F Corpet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robert, X" uniqKey="Robert X">X Robert</name></author><author><name sortKey="Gouet, P" uniqKey="Gouet P">P Gouet</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Utrecht (province)</li></region><settlement><li>Utrecht</li></settlement></list><tree><noCountry><name sortKey="Dimaio, Frank" sort="Dimaio, Frank" uniqKey="Dimaio F" first="Frank" last="Dimaio">Frank Dimaio</name><name sortKey="Frenz, Brandon" sort="Frenz, Brandon" uniqKey="Frenz B" first="Brandon" last="Frenz">Brandon Frenz</name><name sortKey="Rey, Felix A" sort="Rey, Felix A" uniqKey="Rey F" first="Félix A." last="Rey">Félix A. Rey</name><name sortKey="Tortorici, M Alejandra" sort="Tortorici, M Alejandra" uniqKey="Tortorici M" first="M. Alejandra" last="Tortorici">M. Alejandra Tortorici</name><name sortKey="Veesler, David" sort="Veesler, David" uniqKey="Veesler D" first="David" last="Veesler">David Veesler</name><name sortKey="Walls, Alexandra C" sort="Walls, Alexandra C" uniqKey="Walls A" first="Alexandra C." last="Walls">Alexandra C. Walls</name></noCountry><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Bosch, Berend Jan" sort="Bosch, Berend Jan" uniqKey="Bosch B" first="Berend-Jan" last="Bosch">Berend-Jan Bosch</name></region><name sortKey="Rottier, Peter J M" sort="Rottier, Peter J M" uniqKey="Rottier P" first="Peter J. M." last="Rottier">Peter J. M. Rottier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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